Firms have pledged to help keep a 20 metre radius of their premises litter-free and alert the council to other litter, graffiti or fly-tipping issues they see nearby.
Tesco in Bourne, Listers Toyota in Grantham, The Cosy Club in Stamford, The Grange Spa in Pointon and The Grantham Journal have all joined a growing band of companies backing the campaign, including McDonalds in Grantham.
SKDC's Cabinet Member for Environment, Cllr Dr Peter Moseley, said: "I'm delighted that more and more businesses are backing the Big Clean. It is a real team effort between the Council, businesses and residents.
"Cleaner towns and villages benefit everyone. They make our district a better place to live, an attractive place to visit, and a great place to invest.
"We hope that residents and shoppers will notice more and more Big Clean window stickers on our high streets, which demonstrate that companies are proud to be on board."
Businesses and residents are being encouraged to continue reporting less loved 'grotspots' so that litter, weeds, fly-tipping and graffiti can be tackled when operations start next week.
To sign up as a business or a volunteer or log a report online by dropping a virtual pin in a map, simply go to www.southkesteven.gov.uk/skbigclean or call 01476 40 60 66.
The campaign is also on social media, follow #SKBigClean